Runx1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comRunx1 ELISA Kit for Rat(Rattus norvegicus)

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Runx1 (Gene name),

Runt-related transcription factor 1 (Protein name ), RUNX1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Runx1(Aml1;Cbfa2);

Protein name:

Runt-related transcription factor 1;

Alternative:

Core-binding factor subunit alpha-2(CBF-alpha-2);Acute myeloid leukemia 1 protein;Polyomavirus enhancer-binding protein 2 alpha B subunit(PEA2-alpha B;PEBP2-alpha B);Oncogene AML-1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with KAT6A and KAT6B. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1 (By similarity). Interacts with YAP1 and HIPK2. Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity.

Function:

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Inhibits KAT6B-dependent transcriptional activation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

450

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q63046

Pfam:

PF00853

UniGene:

Rn.11201

KEGG:

rno:50662

String:

Q63046

STRING:

10116.ENSRNOP00000002313

Uniprot:

Q63046

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ELISA Kit for Rat Runt-related transcription factor 1

Cat.:

E10487h

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96T

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ELISA Kit for Rat Runt-related transcription factor 1

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E10487m

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ELISA Kit for Rat Runt-related transcription factor 1

Cat.:

E10487r

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96T

CLIA Kit for Rat Runt-related transcription factor 1

Cat.:

U10487m

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96T

CLIA Kit for Rat Runt-related transcription factor 1

Cat.:

U10487h

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MSDS:

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Packing:

96T

CLIA Kit for Rat Runt-related transcription factor 1

Cat.:

U10487r

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96T

Polyclonal Antibody for Rat Runt-related transcription factor 1

Cat.:

P10487Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Runt-related transcription factor 1

Cat.:

P10487Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Runt-related transcription factor 1

Cat.:

P10487Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Runt-related transcription factor 1

Protein for Rat Runt-related transcription factor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"AML1 is expressed in skeletal muscle and is regulated by innervation."
Zhu X. , Yeadon J.E. , Burden S.J.
Mol. Cell. Biol.14:8051-8057(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
strain: Sprague-Dawley.
tissue: Skeletal muscle.

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